Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease
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چکیده
منابع مشابه
Gab Adapter Proteins as Therapeutic Targets for Hematologic Disease
The Grb-2 associated binder (Gab) family of scaffolding/adaptor/docking proteins is a group of three molecules with significant roles in cytokine receptor signaling. Gabs possess structural motifs for phosphorylation-dependent receptor recruitment, Grb2 binding, and activation of downstream signaling pathways through p85 and SHP-2. In addition, Gabs participate in hematopoiesis and regulation o...
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ژورنال
عنوان ژورنال: Advances in Hematology
سال: 2012
ISSN: 1687-9104,1687-9112
DOI: 10.1155/2012/380635